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Short Talks - Insights on Platelet Biology
  Saturday, April 6, 2024           10:30 - 11:30 AM
Moderators
Cathy Hayward, Viktor Prifti
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Presentations
10:45 DNA DAMAGE REPAIR INHIBITION: A CATALYST FOR ENHANCED MEGAKARYOPOIESIS AND THROMBOPOIESIS
Roelof H Bekendam1,2, Andrew Stone1, Clementine Payne1, Virginia Camacho1, Isabelle Becker1, Estelle Carminita1, Maria Barrachina1, Kellie Machlus1, Joseph Italiano1. 1Vascular Biology Program, Boston Children's Hospital, Boston, MA, USA 2Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA
11:00 NOVEL MECHANISM OF THROMBOSIS AND HEMOSTASIS INVOLVING PLATELET ALPHA-DYSTROGLYCAN
Viktor Prifti1,2, Aron A. Shoara2,3, Reid C. Gallant4, Sladjana Slavkovic2,3, Kanwal Singh3, Margaret Rand1, Walter Kahr5, Yiming Wang2, Heyu Ni1,2,3. 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 2Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada 3Canadian Blood Services Centre for Innovation, Toronto, ON, Canada 4Department of Medicine, University of Toronto, Toronto, ON, Canada 5Department of Biochemistry, University of Toronto, Toronto, ON, Canada
11:15 UNC9426, A SELECTIVE TYRO3 INHIBITOR, DECREASES HUMAN PLATELET ACTIVATION AND INCREASES SURVIVAL IN A MURINE PULMONARY EMBOLISM MODEL
Samantha Judd1, Stephanie Springborn1, Adam Kidwell1, Deborah DeRyckere2, Douglas K. Graham2, Xiaodong Wang3, Brian Branchford1. 1Versiti Blood Research Institute, Wauwatosa, WI, USA 2Aflac Cancer and Blood Disorders Center and Children's Healthcare of Atlanta, Atlanta, GA, USA 3Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
10:30 EVALUATING DIAGNOSTIC ALGORITHMS FOR HEPARIN-INDUCED THROMBOCYTOPENIA USING TWO COMBINED RAPID AUTOMATED ASSAYS
Anna-Lise Bissola1,2, Yi Zhang1,3, Madison Cranstone2,4, Donald Arnold1,2, Ishac Nazy1,2. 11. Faculty of Medicine, Michael DeGroote School of Medicine, McMaster University, 2. Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada 2Faculty of Medicine, Michael DeGroote School of Medicine, McMaster University, 3. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada 32. Michael G. DeGroote Centre for Transfusion Research, McMaster University, 4. Department of Statistics and Actuarial Science, University of Waterloo,, Hamilton, ON, Canada 41. Faculty of Medicine, Michael DeGroote School of Medicine, McMaster University, 2. Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada 51. Faculty of Medicine, Michael DeGroote School of Medicine, McMaster University, 2. Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada