| Pitfalls and Considerations for Thrombophilia Testing--how can laboratories support patients? (purpura fulminans, acute DIC, APAS, interferences etc.) Donna Castellone. |
Abstract
Pitfalls in Thrombophilia Testing: How can laboratories support patients?
Donna D Castellone, MS, MASCP, MLS(ASCP)SH
Hereditary thrombophilia is rare, most cases are acquired. Thrombophilia testing is complex, expensive and several tests must be performed to make a diagnosis. Testing should be performed when it supports outcomes for treatment. Using testing algorithms and adhering to guidelines can guide initial testing that is best for patients. Genetic testing may also be utilized however patients should be aware of the ramifications of having that information. It is the responsibility of the laboratory to provide robust and quality testing to aid in the diagnosis and treatment of these disorders. Testing methodology should be chosen to best reflect the patient population being evaluated. Implementing quality indicators to minimize preanalytical, analytical and post analytical issues will provide the most accurate patient results. Understanding what risks the laboratory is willing to accept with testing can also be important in implementing and maintaining these tests. Participating and understanding the information provided by proficiency testing is a tool in quality practices. All this information can aid in supporting patients in the diagnosis of thrombophilia.
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