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Short Talks - Bleeding Back to the Basics
Moderators
Bobby Lee, Kyumin Lee
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Presentations
10:30 GERMINAL CENTER AND NON-GERMINAL CENTER B CELL RESPONSE TO FACTOR VIII IN HEMOPHILIA A PATIENTS
Maya Maarouf1, Ian Smith1, Wallace H Baldwin1, John F Healey1, Ernest T Parker1, Courtney Cox1, Robert F Sidonio, Jr1, Karen L Zimowski1, Glaivy Batsuli2, Bhavya S Doshi3, Shannon L Meeks1, Seema R Patel1. 1Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta/Emory University School of Medicine, Atlanta, GA, USA 2Stanford University, Palo Alto, CA, USA 3Department of Pediatrics, Division of Hematology, Children’s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
10:45 ENHANCED ACTIVATION OF FVIII POSITIVELY IMPACTS CLOT FORMATION IN VIVO USING HEMOPHILIA A MICE
Lacramioara Ivanciu1, 2, Mettine H.A. Bos1, Rodney M. Camire1, 2. 1The Children's Hospital of Philadelphia, Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Philadelphia, PA, USA 2University of Pennsylvania, Department of Pediatrics, Philadelphia, PA, USA
11:00 INTRINSIC XASE LIGAND INTERACTIONS IMPACT FVIIIA REGULATION
John J Morris1,2, Nicole A Parsons2, Robert J Davidson1, Lindsey A George1,2. 1Children's Hospital of Philadelphia, Philadelphia, PA, USA 2University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
11:15 PROCOAGULANT RESCUE OF HEMOPHILIA B CAUSING FACTOR IX VARIANTS BY FACTOR FVIII MIMETICS
Kyumin Lee1,2, Yani Suber1,2, Julia Q. Chau1,2, Sebastian E. Leyes Porello1,2, Bhavya S. Doshi1,2, Ben J. Samelson-Jones1,2. 1The Children’s Hospital of Philadelphia, Division of Hematology, Philadelphia, PA, USA 2University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA