This symposium will highlight current and emerging strategies to improving the diagnosis and management of von Willebrand disease (VWD) from genetics to long-term prophylaxis The program will begin with address advances in VWD diagnostics, focusing on the clinical utility of VWF genotyping. The investigator-initiated VUS study will be presented, evaluating whether VWF genotyping improves diagnostic accuracy, variant interpretation, treatment decisions, bleeding-related quality of life, and family testing.

The symposium will also explore iron deficiency as an important and often under-recognized comorbidity in VWD. The final part of the symposium will focus on prophylactic treatment strategies in VWD, reviewing data from the WIL-31 and WIL-33 studies demonstrating the effectiveness of VWF concentrate prophylaxis across VWD subtypes and age groups. Planned US-based cost-effectiveness analysis and of concepts of personalized prophylaxis, including the design and rationale of the POPPK study, will be also introduced.

The session will be chaired by Veronica Flood, with faculty Robert Sidonio and Jill Johnsen.