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Thank you for attending THSNA 2026. The virtual meeting is now closed.
Thank you for attending THSNA 2026. The virtual meeting is now closed.
Presentation Details
| Heparin Induced Thrombocytopenia in Cardiac Surgery Patients- A National Inpatient Sample Database Study From 2016-2021 Sruthi/P Ramanan1, Kalaivani Babu2, Srinishant Rajarajan2, Yin Yue3, Deep Shah1. 1AHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA, USA.2Department of Internal Medicine, Allegheny Health Network, Pittsburgh, PA, USA.3Allegheny Health Network, Pittsburgh, PA, USA |
Abstract
Background: Heparin induced thrombocytopenia (HIT) is a rare but serious immune mediated complication of treatment with heparin and its analogs. The antibodies that are developed target platelet factor 4 and heparin complexes leading to a prothrombotic state which paradoxically increases the risk of thrombosis despite a declining platelet count. The instance if it varies with reported rates ranging from less than 0.1% to 5% depending on the patient population. Surgical patients, particularly those undergoing cardiopulmonary bypass, are at greatest risk of HIT compared to other populations. Given the rarity of its incidence, large-scale database studies are essential tools for evaluating the true scope of HIT in any population. Results: This study was conducted using the National Inpatient Sample (NIS) database. This study included a total of 3,904,829 patients between the years 2016-2021 who were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-10 CM) procedure codes. There were 3, 897, 224 (99.81%) patients without HIT and 7605 (0.19%) patients with HIT. There were no statistical differences in baseline characteristics between the patients with and without HIT. Our study did show that patients with HIT had worse clinical outcomes with the incidence of wound infection being 0.92% in the HIT group compared to 0.11% in the non HIT patients with a (P<.0001) in addition to confirming prior findings of increased hospital length of stay and substantially increased hospital charges. Conclusion: Our study reinforces the significant clinical and economic burden of HIT in patients undergoing cardiac surgery. The need for improved prevention and management strategies for HIT patients is highlighted by the extended length of stay, higher complication rates, and substantial increase in the cost of hospitalization.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.