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Thank you for attending THSNA 2026. The virtual meeting is now closed.
Thank you for attending THSNA 2026. The virtual meeting is now closed.
Presentation Details
| Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients - A National Inpatients Sample Database Study Sruthi/P Ramanan1, Kalaivani Babu2, Srinishant Rajarajan2, Yin Yue3, Deep Shah1. 1AHN Cancer Institute, Allegheny Health Network, Pittsburgh, PA, USA.2Department of Internal Medicine, Allegheny Health Network, Pittsburgh, PA, USA.3Allegheny Health Network, Pittsburgh, PA, USA |
Abstract
Background: Heparin induced thrombocytopenia (HIT) is an autoimmune condition characterized by formation of autoantibodies against heparin platelet factor 4 complexes. Binding of IgG antibodies to the heparin platelet factor 4 complex leads to platelet activation creating hypercoagulable state resulting in life-threatening thrombosis. Patients undergoing orthopedic procedures routinely receive chemical thrombosis prophylaxis to prevent complications like DVT and PE placing them at higher risk of developing HIT. Results: A total of 699,745 patients who underwent orthopedic surgery between the years 2016 to 2021 were identified using the National Inpatient Sample (NIS) database. There were 120 (0.02%) patients who were diagnosed with HIT. There were no statistically significant differences in the demographic characteristics between the HIT and the non-HIT group. Patients with HIT had a significantly longer hospital stay (8.38 days v/s 3.63 days) and higher cost of hospitalization compared to with a non- HIT group ($137,441 v/s $87,358). Blood loss anemia was significantly more frequent in the HIT group (50%) compared to the non- HIT (23.08%) group. Conclusion: HIT is associated with significant adverse outcomes; longer hospital stays and higher cost of hospitalization especially in orthopedic surgery patients. These findings outline the need for heightened awareness, prompt diagnosis and appropriate management of HIT, especially in high-risk populations.
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