Mechanistic population PK/PD modeling of factor XI-targeting monoclonal antibodies REGN7508CAT and REGN9933A2 in healthy volunteers: A foundation for dose selection and clinical translation
Oleg Milberg, Hisham Abdallah, Rachel Kudgus Lokken, Robert Dingman, Karoline A. Meagher, Michael E. Burczynski, Ethan Marin, Aaron Kithcart, David E. Gutstein
Session: Posters/Exhibits/Break
- Posters/Exhibits/Break (On-Demand)
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Determination of REGV131-LNP1265–derived human factor IX activity using one-stage clotting and chromogenic substrate assays: Results from a comparative field study
Karoline A. Meagher, Robert J. Durso, KehDih Lai, Dan Chalothorn, Natalie Niepoth, Shane McCarthy, Sara Hamon, David E. Gutstein, Meagan P. O’Brien, Stefan Tiefenbacher, William Pickering, Mary Robinson, Michael E. Burczynski
Session: Posters/Exhibits/Break
- Posters/Exhibits/Break (On-Demand)
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Mechanistic population PK/PD modelling of REGN7508CAT supports dose selection for sustained FXI suppression and aPTT response in healthy volunteers and post-surgical VTE-prevention participants
Oleg Milberg, Hisham Abdallah, Rachel Kudgus Lokken, Robert Dingman, Karoline A. Meagher, Poulabi Banerjee, Michael E. Burczynski, Ethan Marin, Aaron Kithcart, David E. Gutstein
Session: Posters/Exhibits/Break
- Posters/Exhibits/Break (On-Demand)
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Exploratory analysis of intrinsic pathway-triggered thrombin generation inhibition in healthy volunteers and patients post-total knee arthroplasty who received REGN9933A2 and REGN7508CAT
Karoline A. Meagher, Kusha Mohammadi, Dateng Li, Ethan Marin, Aaron Kithcart, Meagan P. O’Brien, Selin Somersan-Karakaya, KehDih Lai, Dan Chalothorn, Robert J. Durso, Michael E. Burczynski, Poulabi Banerjee, David E. Gutstein
Session: Short Talks - Emerging Therapeutics and Prophylactic Strategies in Coagulation Disorder
- Short Talks (Live Event)
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