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| Role of fibrinogen in liver injury Lauren Poole. |
Abstract
Acute and chronic liver injury are associated with intrahepatic accumulation of the coagulation factor fibrin(ogen). It was long-assumed that fibrin(ogen) is deposited in the injured liver as a result of coagulation activity, i.e., thrombin-driven fibrin polymerization and cross-linking by the transglutaminase Factor XIIa. Moreover, because these intrahepatic fibrin(ogen) deposits typically co-localize with areas of liver injury, it was proposed that fibrin(ogen) contributes to the pathogenesis of liver injury. The aim of this presentation is to highlight recent advances in our understanding of the mechanisms driving hepatic fibrin(ogen) accumulation in the context of acute and chronic toxicant-induced liver injury. Furthermore, the role of fibrin(ogen) in liver injury and repair, including the contribution of post-translational modifications, will be discussed.
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