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| Platelets as Liquid Biopsies: Multi-Omic Signatures in Human Disease Anandi Krishnan. |
Abstract
Platelets are peripherally accessible, nucleic acid-bearing cells that reflect the molecular state of their parent megakaryocytes, the bone marrow microenvironment, and systemic disease. Our work applies RNA sequencing, proteomics, and machine learning to characterize platelet molecular signatures across hematologic and inflammatory disease contexts. In myeloproliferative neoplasms, integrated proteo-transcriptomic profiling identifies subtype-specific signatures, validates impaired proteostasis and unfolded protein response pathways as disease mediators, and enables peripheral blood-based classification of disease subtypes including myelofibrosis. Extending beyond hematologic malignancy, platelet multi-omics offers a scalable, minimally invasive platform for biomarker discovery, disease stratification, and therapeutic target nomination across human disease
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